abstract：:Pilomatrix (pilomatrical) carcinoma is a rare cutaneous adnexal tumor with matrical differentiation and recurrent and metastatic potential. Sarcomatoid pilomatrix carcinoma is a rare variant which shows a sarcomatoid component intermingling with the epithelial one. There are only 4 cases previously published. We prese...

journal_title：Journal of cutaneous pathology

authors： Fernandez-Flores A,Cassarino DS

更新日期：2018-07-01 00:00:00

abstract：:LL-37 is a naturally occurring 37-amino-acid peptide that is part of the innate immune system in human skin. Preclinical studies have showed that intra-tumoral injections of LL-37 stimulate the innate immune system by activation of plasmacytoid dendritic cells, which mediate tumor destruction. LL-37 intra-tumoral inje...

journal_title：Journal of cutaneous pathology

authors： Dolkar T,Trinidad CM,Nelson KC,Amaria RN,Nagarajan P,Torres-Cabala CA,Ivan D,Prieto VG,Tetzlaff MT,Curry JL,Aung PP

更新日期：2018-07-01 00:00:00

abstract：:Immunotherapies targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and the programmed cell death 1 (PD-1) receptor and its ligand (PD-L1) have showed significant therapeutic benefit in patients with clinically advanced solid malignancies, including melanoma. However, immune-related adverse events (irAE) ar...

journal_title：Journal of cutaneous pathology

authors： Trinidad C,Nelson KC,Glitza Oliva IC,Torres-Cabala CA,Nagarajan P,Tetzlaff MT,Ivan D,Hwu WJ,Prieto VG,Curry JL,Aung PP

更新日期：2018-07-01 00:00:00

abstract：:Epithelioid cells with foamy cytoplasm (histiocytoid features) are typical histopathologic findings among benign and malignant histiocytic neoplasms such as xanthoma and atypical fibroxanthoma. However, these changes are unusual in melanoma, which is typically composed of nested and variably pigmented atypical epithel...

journal_title：Journal of cutaneous pathology

authors： Farah M,Nagarajan P,Torres-Cabala CA,Curry JL,Amaria RN,Wargo J,Tawbi H,Ivan D,Prieto VG,Tetzlaff MT,Aung PP

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Genital basal cell carcinoma (BCC) accounts for <1% of all BCCs. We aimed to elucidate the pathogenesis of genital BCC. METHODS:We retrospectively evaluated cases of pathologically diagnosed genital BCC between 1990 and 2016 in an Asian tertiary referral center. The control group was composed of consecutive...

journal_title：Journal of cutaneous pathology

authors： Wang YJ,Tang TY,Wang JY,Huang YK,Wu YH

更新日期：2018-06-19 00:00:00

abstract：:Superficial acral fibromyxoma (SAFM) is an uncommon mesenchymal soft tissue tumor with a predilection for the acral extremites and nail bed involvement. SAFM is diagnosed with clinicopathological and immunohistochemical examination. Awareness of this rare tumor is important because of amounts of benign and malignant n...

journal_title：Journal of cutaneous pathology

authors： Kara Polat A,Gore Karaali M,Turgut Erdemir AV,Koku Aksu AE,Leblebici C,Gurel MS

更新日期：2018-06-01 00:00:00

abstract：:Mycosis fungoides in palmoplantar localization (MFPP) is a rare variant of MF that is confined to the hands and feet. Patients commonly receive treatment over many years for suspected palmoplantar dermatitis before the diagnosis is made. Most MFPP patients remain at patch or plaque stage, and often respond to treatmen...

journal_title：Journal of cutaneous pathology

authors： Pham AK,Carter JB,Ratcliffe NR,Fuld AD,Lansigan F,Burnside NJ,Guill MA 3rd,Zug KA,Jarvis LA,LeBlanc RE

更新日期：2018-06-01 00:00:00

abstract：:Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue tumor that arises primarily on the trunk and extremities but seldom on the scalp. Several variants of DFSP have been described, including myxoid DFSP. Although typical DFSP may have focally myxoid areas, myxoid DFSP, in which most of the stroma is myxoid, is...

journal_title：Journal of cutaneous pathology

authors： Tran P,Henderson GP,McLemore M

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Primary cutaneous apocrine cribriform carcinoma (PCACC) is a rare tumor, clinically appearing as a solitary nodule, mostly involving extremities of females and this lesion usually raises a differential diagnosis with metastatic cribriform carcinomas, especially breast cancer. OBJECTIVE:To study GATA3 expres...

journal_title：Journal of cutaneous pathology

authors： Llamas-Velasco M,Pérez-Gónzalez YC,Daudén E,Rütten A

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:The Wnt signaling pathway has been implicated in the pathogenesis of pilomatrical tumors. Lymphoid enhancer-binding factor 1 (LEF-1) is a downstream component of this pathway, and Caudal-related homeobox transcription factor 2 (CDX2) has been postulated to regulate it, but little is known about expression of...

journal_title：Journal of cutaneous pathology

authors： Tumminello K,Hosler GA

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) represent 2 entities that cause primary cicatricial alopecia. These entities are clinically different; nevertheless, the literature suggests that FFA represents a form of LPP. The main argument in support of this hypothesis is that previous studi...

journal_title：Journal of cutaneous pathology

authors： Gálvez-Canseco A,Sperling L

更新日期：2018-05-01 00:00:00

abstract：:Glomus tumors are rare, soft-tissue neoplasms arising from the thermoregulatory neuromyoarterial glomus bodies. They are commonly observed in the extremities and typically present with symptoms of cold hypersensitivity, pain and localized tenderness. Intraneural glomus tumors (INGTs) are even rarer. Here we review the...

journal_title：Journal of cutaneous pathology

authors： Muthiah S,Hussain R,Stefanos N,Husain A

更新日期：2018-04-01 00:00:00

abstract：:Large cell neuroendocrine carcinoma (LCNEC) of the larynx is an aggressive form of neuroendocrine carcinoma that affects smokers at an average age of 60 years. LCNEC is characterized by large cells with round to ovoid nuclei distributed in a trabecular or nested growth pattern. Previously, laryngeal LCNEC and atypical...

journal_title：Journal of cutaneous pathology

authors： Dunn A,Broadfoot BG,Hunt J,Kaley JR,Atiq O,Gutta NB,Wang X,Gardner JM,Shalin SC

更新日期：2018-03-01 00:00:00

abstract：:Malignant mesothelioma (MM) is an aggressive and invasive neoplasm primarily affecting the pleura, peritoneum and pericardium. While mesothelioma commonly metastasizes to visceral organs, it has rarely been documented to involve the skin and subcutaneous tissue. There is a paucity of reports of cutaneous metastatic me...

journal_title：Journal of cutaneous pathology

authors： Ward RE,Ali SA,Kuhar M

更新日期：2017-12-01 00:00:00

abstract：:Calciphylaxis is a rare syndrome of vascular calcification with thrombosis that occurs most often in patients with end-stage renal disease, and it frequently portends a guarded prognosis. Rarely, nonuremic calciphylaxis (NUC) may occur; in this context, a strongly supportive histology is crucial in establishing the di...

journal_title：Journal of cutaneous pathology

authors： Nathoo RK,Harb JN,Auerbach J,Guo R,Vincek V,Motaparthi K

更新日期：2017-12-01 00:00:00

abstract：:Immunotherapies targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and the programmed cell death 1 (PD-1) receptor and its ligand (PD-L1) have showed substantial therapeutic benefit in patients with clinically advanced solid malignancies. However, autoimmune toxicities are common and often significant adve...

journal_title：Journal of cutaneous pathology

authors： Tetzlaff MT,Jazaeri AA,Torres-Cabala CA,Korivi BR,Landon GA,Nagarajan P,Choksi A,Chen L,Uemura M,Aung PP,Diab A,Sharma P,Davies MA,Amaria R,Prieto VG,Curry JL

更新日期：2017-12-01 00:00:00

abstract：:Cutaneous lymphadenoma is an uncommon benign neoplasm often considered to be an adamantinoid variant of trichoblastoma. Lesions present in both sexes, between 14 and 87 years of age, and are mainly located on the head and neck. Cases in children are rare and there is only 1 previous case of a congenital lymphadenoma. ...

journal_title：Journal of cutaneous pathology

authors： Fernandez-Flores A,Nicklaus-Wollenteit I,Sathishkumar D,Diba V,Richard B,Carr R,Moss C,Nagy A,Ogboli M,Colmenero I

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:We present herein a series of 14 lesions showing overlapping features with the newly defined benign cutaneous mesenchymal neoplasm labeled as fibroblastic connective tissue nevus (FCTN). METHODS AND RESULTS:Total of 8 patients were male and 5 were female, ranging in age from 1 to 56 years. Lesions appeared ...

journal_title：Journal of cutaneous pathology

authors： Pennacchia I,Kutzner H,Kazakov DV,Mentzel T

更新日期：2017-10-01 00:00:00

abstract：:Cutaneous syncytial myoepithelioma is a recently described rare tumor of the dermis. It is derived and composed purely of myoepithelial cells and shows a characteristic syncytial growth pattern of neoplastic cells with little intervening stroma and no recognizable ductal structures. It represents a diagnostic challeng...

journal_title：Journal of cutaneous pathology

authors： Alomari AK,Brown N,Andea AA,Betz BL,Patel RM

更新日期：2017-10-01 00:00:00

abstract：:Anaplastic large cell lymphoma (ALCL) is a CD30+ T-cell non-Hodgkin lymphoma with 2 main clinical presentations: primary cutaneous ALCL (pcALCL) and systemic ALCL (sALCL). While rare cases of myxoid sALCL have been reported, there are no previous cases of myxoid pcALCL reported. We present 2 unusual cases of pcALCL sh...

journal_title：Journal of cutaneous pathology

authors： Fernandez-Flores A,Eginli A,Cassarino DS

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Merkel cell carcinoma (MCC) is an aggressive neoplasm, which is often associated with Merkel cell polyomavirus (MCPyV). Programmed death-1 (PD-1) and its ligand PD-L1 are key players of the tumor microenvironment (TME). METHODS:Fourteen paraffin-embedded tissue samples of MCC were stratified by their MCPyV ...

journal_title：Journal of cutaneous pathology

authors： Mitteldorf C,Berisha A,Tronnier M,Pfaltz MC,Kempf W

更新日期：2017-09-01 00:00:00

abstract：:Polarizable calcium oxalate (CaOx) crystals have been well documented in breast biopsies, generally associated with benign apocrine metaplasia. In contrast, polarizable crystals are only rarely reported in skin adnexal neoplasms. We report 3 different cases of sweat gland tumors with polarizable crystals morphological...

journal_title：Journal of cutaneous pathology

authors： Johnson G,Gardner JM,Shalin SC

更新日期：2017-08-01 00:00:00

abstract：:Dermal non-neural granular cell tumor (NNGCT) was first described in 1991 as an S100-negative polypoid non-melanocytic tumor. Although originally introduced in the literature as a primary cutaneous tumor, it was later emphasized that such qualification could not be held until the line of differentiation was clarified....

journal_title：Journal of cutaneous pathology

authors： Fernandez-Flores A,Cassarino DS,Riveiro-Falkenbach E,Rodriguez-Peralto JL,Fernandez-Figueras MT,Monteagudo C

更新日期：2017-06-01 00:00:00

abstract：:Adult-onset Still disease (AOSD) is a rare autoinflammatory syndrome characterized by recurring fevers, arthralgia, and consistent laboratory abnormalities that include leukocytosis and hyperferritinemia. Skin findings accompany the disease in nearly 90% of the cases. Early reports described evanescent, pruritic, salm...

journal_title：Journal of cutaneous pathology

authors： Santa E,McFalls JM,Sahu J,Lee JB

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Chronic amastigote-negative cutaneous leishmaniasis (CL) is a diagnostic challenge, as the parasite load may be low, or absent in biopsy tissue sections. METHODS:A series of consecutive biopsy specimens, taken from 130 patients with a diagnosis of granulomatous dermatitis of unknown etiology, were reviewed....

journal_title：Journal of cutaneous pathology

authors： Tomasini C,Moneghini L,Barbui AM

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Morphea (localized scleroderma) and eosinophilic fasciitis (EF) are rare fibrosing disorders which may present a diagnostic challenge. While histopathologic features are often distinct, in some cases there may be overlap. T-cells contribute to etiopathogenesis of both autoimmune conditions. We sought to dete...

journal_title：Journal of cutaneous pathology

authors： Moy AP,Maryamchik E,Nikolskaia OV,Nazarian RM

更新日期：2017-06-01 00:00:00

abstract：:Folliculo-sebaceous hamartomas comprise a series of entities whose boundaries are imprecise. We present the clinical case of a folliculo-sebaceous cystic hamartoma of genital localization where the diagnosis was established based on the epithelial proliferation, but mostly, on the characteristic stroma. Because this l...

journal_title：Journal of cutaneous pathology

authors： Alegría-Landa V,Jo-Velasco M,Prieto-Torres L,Requena L

更新日期：2017-05-01 00:00:00

abstract：:Nivolumab is a programmed cell death receptor-1 (PD-1) antibody used in the treatment of metastatic or unresectable melanoma. Cutaneous reactions are the most common adverse events reported with these agents and are rarely severe or life-threatening. Here we present a case report describing the clinicopathological fin...

journal_title：Journal of cutaneous pathology

authors： Vivar KL,Deschaine M,Messina J,Divine JM,Rabionet A,Patel N,Harrington MA,Seminario-Vidal L

更新日期：2017-04-01 00:00:00

abstract：:We present the case of a 28-year-old male with a history of human immunodeficiency virus (HIV) with a 1-month history of a steadily enlarging, firm painful lesion on the right posterior shoulder. The patient was initially treated for cellulitis given his clinical picture. Histopathologic examination revealed an angioc...

journal_title：Journal of cutaneous pathology

authors： Malviya N,Rainwater YB,Vandergriff T,Mauskar MM

更新日期：2017-03-01 00:00:00

abstract：:True human tails are rare vestigial structures that are typically removed in childhood. Here a case is presented in which an inconspicuous sacrococcygeal tail was incidentally discovered in late adulthood. A 56-year-old man with no significant past medical history presented to a dermatology clinic with a chief complai...

journal_title：Journal of cutaneous pathology

authors： Robinson CG,Duke TC,Allison AW

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Studies on the precise cause of increased melanization in pigmented basal cell carcinomas (BCC) are limited. We aimed to determine whether the cause of melanization is from increased number of melanocytes or increased melanin pigment, and if there is a difference in the number of melanocytes on different sun...

journal_title：Journal of cutaneous pathology

authors： Brankov N,Prodanovic EM,Hurley MY

更新日期：2016-12-01 00:00:00

abstract：:A cystic panfolliculoma is a benign follicular neoplasm which recapitulates several portions of the hair follicle. The patient was a 64-year-old Caucasian female who presented with a new growth on her right forearm. The lesion had slowly enlarged over the previous 11 months. She complained of it bleeding on several oc...

journal_title：Journal of cutaneous pathology

authors： Neill B,Bingham C,Braudis K,Zurowski S

更新日期：2016-12-01 00:00:00

abstract：:Until recently the number of patients with syphilis has been diminishing. Although that trend has reversed cases of tertiary syphilis are rare and often difficult to diagnose as a substantial number of patients will have a negative rapid plasma reagin. Histologically, cutaneous lesions in late stage syphilis exist in ...

journal_title：Journal of cutaneous pathology

authors： Boyd AS

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:The histopathologic features of tinea vary widely and its diagnosis could be easily missed if the index of suspicion is not high. We aimed in this study to detect histopathologic features that could be a clue for diagnosis METHODS:We retrospectively reviewed 103 cases of tinea, confirmed by Periodic acid-Sc...

journal_title：Journal of cutaneous pathology

authors： Elbendary A,Valdebran M,Gad A,Elston DM

更新日期：2016-10-01 00:00:00

abstract：:Free-living amebae are ubiquitous in our environment, but rarely cause cutaneous infection. Balamuthia mandrillaris has a predilection for infecting skin of the central face. Infection may be restricted to the skin or associated with life-threatening central nervous system (CNS) involvement. We report a case of a 91-y...

journal_title：Journal of cutaneous pathology

authors： Chang OH,Liu F,Knopp E,Muehlenbachs A,Cope JR,Ali I,Thompson R,George E

更新日期：2016-10-01 00:00:00

abstract：:Eccrine nevi are rare hamartomas characterized by an increase in the number or size of eccrine glands. A polypoid form located in the coccygeal area has been described in a few cases and termed coccygeal polypoid eccrine nevus (CPEN). No association with internal malformations was reported in any of these cases. We de...

journal_title：Journal of cutaneous pathology

authors： Frouin E,Riviere B,Maillet O,Willems M,Kalfa N,Costes V,Bessis D

更新日期：2016-08-01 00:00:00

abstract：:Polymorphous sweat gland carcinoma (PSGC) is a rare adnexal neoplasm with characteristic variegated histopathologic findings and low-grade clinical behavior. First described in 1994, only 11 cases have been reported in the literature. It is named for the multiplicity of architectural patterns that may be present: soli...

journal_title：Journal of cutaneous pathology

authors： Walker A,Mesinkovska NA,Emanuel PO,Vidimos A,Billings SD

更新日期：2016-07-01 00:00:00

abstract：:Breast implant-associated anaplastic large cell lymphoma (ALCL) is a newly described clinical and pathologic entity that typically presents as seroma in the fibrous scar around the implant. Less frequently, it presents as a solid peri-implant mass, and there have been no reports to date of cutaneous lesions as the pre...

journal_title：Journal of cutaneous pathology

authors： Alcalá R,Llombart B,Lavernia J,Traves V,Guillén C,Sanmartín O

更新日期：2016-07-01 00:00:00

abstract：:Goltz syndrome (focal dermal hypoplasia) is an X-linked dominant disorder that is classically associated with yellowish papules representing fat herniation (superficial adipocytes). We report a series of three cases, with clinicopathologic correlation of biopsies from Blaschkoid streaks. A range of histopathologic fea...

journal_title：Journal of cutaneous pathology

authors： Ko CJ,Antaya RJ,Zubek A,Craiglow B,Damsky W,Galan A,McNiff JM

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Chronic urticaria is a condition with many inciting factors and often presents a therapeutic challenge to clinicians. In addition to a central role for mast cells, an immune dysregulated state related to cytokine/chemokine alterations is increasingly being recognized. METHODS:Biopsies of chronic urticaria (...

journal_title：Journal of cutaneous pathology

authors： Moy AP,Murali M,Nazarian RM

更新日期：2016-04-01 00:00:00